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High expression of P-glycoprotein in ENKTCL has been suggested to be the mechanism for its intrinsic drug resistance. ENKTCL is notorious for its resistance to anthracycline-based chemotherapy, including cyclophosphamide, adriamycin, and vincristine. Issues of quality control and technical difficulties will also be discussed, along with future prospects in the molecular diagnosis and treatment of NKTCL.Įxtranodal natural killer (NK)/T-cell lymphoma (NKTCL) is a highly aggressive non-Hodgkin lymphoma that is prevalent in Asia and South America and is characterized by a high relapse rate as well as a poor prognosis. This article will review the latest molecular findings in NKTCL and recent advances in the field of molecular diagnosis in NKTCL. The molecular findings could potentially influence the traditional chemoradiotherapy approach, which is known to be associated with significant toxicity.
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The adoption of high-throughput sequencing has allowed us to gain more insight into the molecular mechanisms of ENKTCL, which largely involve chromosome deletion and aberrations in Janus kinase (JAK)-signal transducer and activator of transcription (STAT), programmed cell death protein-1 (PD-1)/PD-ligand 1 (PD-L1) pathways, as well as mutations in tumor suppressor genes. Epstein–Barr virus (EBV) infection has long been proposed as the major etiology of lymphomagenesis. It occurs in two pathological forms, namely, extranodal NKTCL (ENKTCL) and aggressive NK leukemia, according to the latest World Health Organization (WHO) classification. Features of Gifox 1.Natural killer (NK)/T-cell lymphoma (NKTCL) is an aggressive malignancy with unique epidemiological, histological, molecular, and clinical characteristics.
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All in all, Gifox for Mac is really entering and unique way of recording the screen gif and we highly recommend it. After completing the recording, it provides advanced compression options over output quality and file size.
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With lots of controls features users can decide what to record, how to record, screen elements customization, fps, and looping. With the help of Gifox 1.4 users can record any area of the screen and capture all the activities in gif format.
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There are many awesome tools added to this great software for making great recording gif. It enables digital artists, graphic designers and instructors to effortlessly deliver their message in less time and less space. It is a great alternative between static images and full-size videos. No graphics editing or technical skills are required to work on this software. Gifox 1.4 for Mac is wonderful software for creating the animated gif. Capture live! Just click to grab the last 30 seconds of video. Create your GIF with just a couple clicks.
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This free app is simple, powerful, and easy enough for pretty much anyone. GIPHY Capture is the best way to create GIFs on your Mac. The Gifox 1.4 for Mac is delightful gif recording and sharing app that records the screen into animated GIF. Many experts consider that Gifox as an innovative application which offers an absolutely new method for screen capturing through the use of several selection.ĭownload Gifox 1.4 for Mac free standalone setup.

Besides, the application also allows users to compress or convert any video files into a GIF format.
